Pharma Deals Review, Vol 2025, No 7 (2025)

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Gilead Sciences Inks US$750 M Deal with Kymera Therapeutics for Novel Oral Molecular Glue CDK2 Degraders

Naini Anand

Abstract


Gilead Sciences has entered into a strategic licensing agreement with Kymera Therapeutics to accelerate the development of a novel molecular glue degrader (MGD) programme targeting cyclin-dependent kinase 2 (CDK2), a protein implicated in tumour growth, for the treatment of breast cancer and other solid tumours. Under the terms of the deal, Kymera is eligible to receive up to US$750 M, including US$85 M in upfront, potential option exercise payments, and tiered royalties on net sales. This deal enables Gilead to enhance its footprint in the oncology space and accelerate global development.

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