Pharma Deals Review, Vol 2012, No 2 (2012)

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Alexion Gains First Potential Drug for Hypophosphatasia via US$1.08 B Enobia Buyout

Heather Cartwright

Abstract


Alexion Pharmaceuticals has agreed to acquire Enobia Pharma for up to US$1.08 B in order to gain access to ENB-0040 (asfotase alpha), an enzyme replacement therapy in Phase II development for hypophosphatasia, an ultra-rare genetic metabolic bone disease for which there are no approved therapies. The drug candidate has thus far demonstrated an impressive safety and efficacy profile. Alexion will pay US$610 M upon deal completion and up to US$470 M upon the achievement of various regulatory and sales milestones.



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