Though majority of bacteria that abound the body are required to protect us from diseases, some of them are pathogenic which might multiply aggressively, damage tissue and cause disease. Bacterial disease is complex, as a pathogen is not exclusive to a disease and neither is a bacterial disease caused by one pathogen. Pathogens develop complete resistance or 50% resistance to continuously used broad-spectrum antibiotics. This article discusses the need for new classes of antibiotics which act by different mechanisms, in order to circumvent the bacteria’s continuing ability to avoid capture.